G Protein-Coupled Receptors in Health and Disease

G Protein-Coupled Receptors in Health and Disease

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G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. They are also responsible for our sensing of exogenous stimuli, including photons and odorants. GPCRs regulate almost every aspect of our physiological functions. It is estimated that 40% to 50% of currently used therapeutic drugs target GPCRs directly or indirectly. Because the current drugs target only a small portion of the GPCRs, opportunities for targeting the remaining GPCRs is enormous. This volume reviews the latest developments in this rapidly advancing field. * This series provides a forum for discussion of new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fieldsIRF4 protein, 95 Isolated growth hormone deficiency (IGHD), 58 categories, 59 GH1 mutations prevalence, 60 J Jaundice, ... 125a€“126 and CDKN2A familial melanoma, 125 cell-surface fluorescence, 105 and DNA repair, 125 and melanocyticanbsp;...

Title:G Protein-Coupled Receptors in Health and Disease
Publisher:Academic Press - 2009-08-05

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